What the research shows
Two blinded, randomized phase III trials compared oral enclomiphene citrate with testosterone gel and placebo in overweight men with low testosterone. After 16 weeks, both active treatments raised testosterone. Sperm concentration stayed in the normal range with enclomiphene and fell with the gel. A comparison of conception rates would require following participants’ reproductive outcomes. Phase III hormone and semen results.
In reviewing EnCyzix, the European regulator also asked whether participants felt or functioned better. Its assessment describes the gap between higher testosterone and demonstrated symptom improvement. EMA assessment of EnCyzix.
Documented formats
The studied substance was oral enclomiphene citrate. The gel in the comparison contained testosterone. EnCyzix was proposed as an oral capsule.
Testing and purity
Look for an assay that separates enclomiphene from zuclomiphene, the other geometric form. The two isomers share a molecular mass, so identification depends on a method that separates them.
How to read a batch reportQuestions about Enclomiphene
Why does the citrate designation matter?
It identifies the salt. An amount expressed as salt and an amount expressed as the active base use different mass conventions.
What does the sperm result tell us?
It describes concentration in semen samples from the trial participants. Pregnancy and live birth are separate outcomes.