What the research shows
Lee and colleagues studied MOTS-c in cell cultures and in mice. In cells, they linked it to changes in folate metabolism and activation of AMPK, a protein involved in energy sensing. Mice given MOTS-c were protected against insulin resistance in high-fat feeding experiments. The authors measured outcomes in those models, leaving the response to the peptide in people a separate question. Read the original MOTS-c experiments.
Documented formats
The study distinguished MOTS-c made by cells from peptide supplied for the intervention experiments. Record which of those forms a figure describes when comparing results.
Testing and purity
Match the reported 16-amino-acid sequence to the test sample. An antibody measurement of naturally present MOTS-c and a mass measurement of a prepared peptide answer different questions.
How to read a batch reportQuestions about MOTS-c
What does mitochondrial mean here?
It describes where the genetic sequence was identified. It does not tell you by itself where the finished peptide was found in a sample.
Was the high-fat-diet result a human weight-loss trial?
It came from mice under controlled feeding conditions. The experiments also measured glucose regulation, which is a separate outcome from body weight.